Emergency services are at the scene of a head-on collision near Tumut.
About 8.40am, two vehicles collided about 10kms north of Tumut on a straight section of the road.
The driver of one vehicle died at the scene, while a passenger has been airlifted to Canberra Hospital in a serious condition.
The driver of the second vehicle suffered non-life-threatening injuries and has been taken to Wagga Wagga Hospital for mandatory testing.
Gocup Road is closed in both directions between Tumut and the Hume Highway and is expected to remain closed for a number of hours.
Diversions around the crash site are in place. Motorists should check www.livetraffic.com for updates.
No other information is available at this time.